| Title | Effects of shock on the pancreatic acinar cell. Cellular and subcellular effects in humans. | | Author(s) | Jones RT, Garcia JH, Mergner WJ, Pendergrass RE, Valigorsky JM, Trump BF | | Source | Arch Pathol 1975 Dec; 99(12):634-44. | | MeSH | Adolescent
Adult
Aged
Female
Humans
Male
Middle Aged
Pancreas
Research Support, U.S. Gov't, P.H.S.
Shock
Shock, Hemorrhagic
Shock, Traumatic
| | Abstract | Pancreatic tissues from 22 patients with a wide variety of types of shock were obtained within minutes of somatic death for light and electron microscopy and for cytochemical studies. By light microscopy, it was difficult to ascertain any differences between the shock groups; however, electron microscopy disclosed subcellular alterations that could be correlated well with the type, severity, and duration of shock. Mild cases of shock or shock of short duration showed mild cell damage, while extreme cases of hemorrhagic or septic shock showed cell death and necrosis. No morphological evidence for lysosomal initiation of damage was seen, but it is clear that the pancreas can undergo severe cell injury during shock that could result in release of further damaging enzymes, most probably from zymogen granules rather than from lysosomes. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 1203034 |
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