| Title | Lymph nodes in gastric B-cell lymphoma: pattern of involvement and early histological changes. | | Author(s) | Ko YH, Han JJ, Noh JH, Ree HJ | | Institution | Department of Diagnostic Pathology, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, Korea. | | Source | Histopathology 2002 Jun; 40(6):497-504. | | MeSH | Adult
Aged
DNA-Binding Proteins
Diagnosis, Differential
Female
Follow-Up Studies
Gene Rearrangement
Humans
Immunoglobulin Heavy Chains
Immunohistochemistry
Lymph Nodes
Lymphoma, B-Cell
Lymphoma, Mucosa-Associated Lymphoid Tissue
Male
Middle Aged
Prognosis
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-6
Receptors, Complement 3d
Research Support, Non-U.S. Gov't
Stomach Neoplasms
Transcription Factors
| | Abstract | AIMS: This study aims to analyse the histological pattern of nodal involvement in gastric B-cell lymphoma and to detect early involvement of the lymph nodes.
METHODS AND RESULTS: Histological findings of 37 resected primary gastric lymphomas with 1313 regional lymph nodes were analysed. The primary tumour was classified into four groups: MALT lymphoma, MALT lymphoma with a minor large B-cell lymphoma (<20%), large B-cell lymphoma with MALT lymphoma, and large B-cell lymphoma without MALT lymphoma. Histological patterns of nodal involvement were divided into sinusoidal, subsinusoidal/marginal, follicular, and diffuse patterns. Semi-nested polymerase chain reaction (PCR) analysis for IgH gene rearrangement was performed. Nodal involvement was found in 2/13 (15%) MALT lymphomas, 5/6 (83%) MALT lymphomas with a minor large B-cell lymphoma, 9/12 (75%) large B-cell lymphomas with MALT lymphoma, and 6/6 (100%) large B-cell lymphomas without MALT lymphoma. The MALT lymphoma and MALT lymphoma with a minor large B-cell lymphoma showed a predominantly sinusoidal and subsinusoidal pattern, whereas diffuse pattern predominated in large B-cell lymphomas without MALT lymphoma and large B-cell lymphomas with MALT lymphoma. The follicular pattern was least common, being observed in 10.2% of large B-cell lymphomas without MALT lymphoma and large B-cell lymphomas with MALT lymphoma. Sinusoidal obliteration with permeation of small monocytoid cells into subsinusoidal zone is a characteristic finding suggesting early nodal involvement of MALT lymphoma.
CONCLUSIONS: Histological patterns of nodal involvement in gastric B-cell lymphoma vary according to the histological grade. Immunostaining for CD20 with or without PCR analysis for IgH gene rearrangement would be a useful ancillary method to confirm lymphomatous involvement. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 12047759 |
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