| Title | Late antenatal carriage of group B Streptococcus by New Zealand women. | | Author(s) | Grimwood K, Stone PR, Gosling IA, Green R, Darlow BA, Lennon DR, Martin DR | | Institution | Department of Paediatrics and Child Health, Wellington School of Medicine and Health Sciences, New Zealand. | | Source | Aust N Z J Obstet Gynaecol 2002 May; 42(2):182-6. | | MeSH | Adolescent
Adult
Analysis of Variance
Anti-Bacterial Agents
Carrier State
Colony Count, Microbial
Confidence Intervals
Disease Transmission, Vertical
Female
Humans
Microbial Sensitivity Tests
New Zealand
Odds Ratio
Pregnancy
Pregnancy Complications, Infectious
Pregnancy Trimester, Third
Prenatal Care
Prevalence
Probability
Prospective Studies
Research Support, Non-U.S. Gov't
Risk Factors
Sampling Studies
Streptococcal Infections
Streptococcus agalactiae
Vaginal Smears
| | Abstract | OBJECTIVES: To determine in New Zealand women the prevalence of group B Streptococcus (GBS) carriage late in pregnancy and to identify GBS colonisation risk factors, antibiotic susceptibility and serotype distribution.
DESIGN: Prospective, observational study.
SETTING: Community and hospital antenatal clinics in Wellington and Auckland during 1998-1999. SAMPLE: Convenience sample of 240 women between 35-37 weeks gestation.
METHODS: Sociodemographic data, obstetric details and anogenital swabs were collected from each subject. Swabs were inoculated into selective media. GBS isolates underwent serotyping and antibiotic susceptibility testing.
RESULTS: Two hundred and forty women (9% Maori, 11% Pacific) aged 15-41 years were recruited. Fifty-two (22%; 95% CI 17, 27) were colonised by GBS. Carriage was independently associated with younger age (59% < or = 30 years; adjusted OR 3.25; 95% CI 1.53, 6.95) and least social deprivation (57% NZ Dep 96 score +/- 3; adjusted OR 1.22; 95% CI 1.06,1.39). All GBS isolates were penicillin-susceptible, but resistance to clindamycin (15%) and erythromycin (7.5%) was detected and associated with serotype V strains. Predominant serotypes were: III (29%), Ia (21%), Ib (20%) and V (20%).
CONCLUSIONS: Approximately 20% of New Zealand women carry GBS late in pregnancy, with young age a major risk factor. Increased risk in the socially advantaged, development of resistance to erythromycin and clindamycin, and emergence of new GBS serotypes are findings with important implications for prevention strategies requiring further confirmation. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 12069147 |
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