| Title | Vasopressin improves survival in a pig model of hypothermic cardiopulmonary resuscitation. | | Author(s) | Schwarz B, Mair P, Raedler C, Deckert D, Wenzel V, Lindner KH | | Institution | Department of Anesthesiology and Critical Care Medicine, Leopold-Franzens-University, Innsbruck, Austria. birgit.schwarz@uibk.ac.at | | Source | Crit Care Med 2002 Jun; 30(6):1311-4. | | MeSH | Animals
Cardiopulmonary Resuscitation
Hypothermia
Lactates
Research Support, Non-U.S. Gov't
Rewarming
Swine
Treatment Outcome
Vasoconstrictor Agents
Vasopressins
| | Abstract | OBJECTIVE: During hypothermic cardiopulmonary resuscitation with a body core temperature <30 degrees C administration of a vasopressor to support coronary perfusion pressure is controversial. The purpose of the current study was to assess the effects of a single 0.4-unit/kg dose of vasopressin on coronary perfusion pressure, defibrillation success, and 1-hr survival in a pig model of hypothermic closed-chest cardiopulmonary resuscitation combined with rewarming.
DESIGN: Prospective, randomized study in an established pig model.
SETTING: University hospital research laboratory.
SUBJECTS: Fifteen 12- to 16-wk-old domestic pigs.
INTERVENTIONS: Pigs were surface cooled to a body core temperature of 26 degrees C and ventricular fibrillation was induced. After 15 mins of untreated cardiac arrest, manual closed-chest cardiopulmonary resuscitation and thoracic lavage with 40 degrees C warmed tap water were started. After 3 mins of external chest compression, animals were assigned randomly to receive vasopressin (0.4 units/kg, n = 8; or saline placebo, n = 7). Defibrillation was attempted 10 mins after drug administration.
MEASUREMENTS AND MAIN RESULTS: Compared with saline placebo treated-animals, coronary perfusion pressure in vasopressin-treated pigs was significantly higher 90 secs (36 +/- 5 mm Hg vs. 7 +/- 4 mm Hg, p =.000) to 10 mins (24 +/- 4 mm Hg vs. 8 +/- 4 mm Hg, p =.000) after drug administration. Restoration of spontaneous circulation and 1 hr survival were significantly higher in vasopressin animals compared with saline placebo (8 of 8 vasopressin pigs vs. 0 of 7 placebo pigs, p <.001).
CONCLUSIONS: A single 0.4-unit/kg dose of vasopressin administered at a body core temperature <30 degrees C significantly improved defibrillation success and 1-hr survival in a pig model of hypothermic cardiopulmonary resuscitation. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 12072687 |
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