Penetration, adhesion, and fusion in mammalian sperm-egg interaction. Science. [Science] Journal article | | Title | Penetration, adhesion, and fusion in mammalian sperm-egg interaction. | | Author(s) | Primakoff P, Myles DG | | Institution | Department of Cell Biology, School of Medicine, University of California-Davis, Davis, CA 95616, USA. pdprimakoff@ucdavis.edu | | Source | Science 2002 Jun 21; 296(5576):2183-5. | | MeSH | Acrosome Reaction
Animals
Cell Adhesion
Cell Membrane
Egg Proteins
Female
Fertilization
Humans
Male
Membrane Glycoproteins
Membrane Proteins
Ovum
Protein Binding
Receptors, Cell Surface
Research Support, U.S. Gov't, P.H.S.
Sperm Motility
Sperm-Ovum Interactions
Spermatozoa
Zona Pellucida
| | Abstract | Fertilization is the sum of the cellular mechanisms that pass the genome from one generation to the next and initiate development of a new organism. A typical, ovulated mammalian egg is enclosed by two layers: an outer layer of approximately 5000 cumulus cells and an inner, thick extracellular matrix, the zona pellucida. To reach the egg plasma membrane, sperm must penetrate both layers in steps requiring sperm motility, sperm surface enzymes, and probably sperm-secreted enzymes. Sperm also bind transiently to the egg zona pellucida and the egg plasma membrane and then fuse. Signaling in the sperm is induced by sperm adhesion to the zona pellucida, and signaling in the egg by gamete fusion. The gamete molecules and molecular interactions with essential roles in these events are gradually being discovered. | | Language | eng | | Pub Type(s) | Journal Article
Review
| | PubMed ID | 12077404 |
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