Paraneoplastic acral vascular syndrome: epidemiologic features, clinical manifestations, and disease sequelae. Journal of the American Academy of Dermatology. [J Am Acad Dermatol] Journal article

Title	Paraneoplastic acral vascular syndrome: epidemiologic features, clinical manifestations, and disease sequelae.
Author(s)	Poszepczynska-Guigné E, Viguier M, Chosidow O, Orcel B, Emmerich J, Dubertret L
Institution	Department of Dermatology, Hôpital Saint-Louis, 1 avenue Claude-Vellefaux, 75475 Paris Cedex 10, France.
Source	J Am Acad Dermatol 2002 Jul; 47(1):47-52.
MeSH	Aged Esophageal Neoplasms Female Fingers Gangrene Humans Incidence Lymphoma Male Middle Aged Paraneoplastic Syndromes Prognosis Risk Factors Survival Rate Syndrome Vascular Diseases
Abstract	BACKGROUND: Acral vascular syndromes associated with malignancy have rarely been reported. OBJECTIVE: Our purpose was to assess the clinical and evolving features of paraneoplastic acral vascular syndromes. Patients and Methods: Two cases of paraneoplastic gangrene are described and analyzed together with previously reported cases identified by a MEDLINE search. RESULTS: Among the 68 patients identified, 40 had gangrene, 16 had acrocyanosis, and 12 had Raynaud's phenomenon. The male to female ratio was 0.89; median age was 59 years. Fingers were affected in 94%. Adenocarcinomas were the predominant associated malignancies (41%), and metastases were observed in 41%. The acral vascular syndromes in 48% of the patients definitively regressed after tumor treatment. Forty-four percent of the patients died within 2 years. A favorable cutaneous outcome was obtained with prostacyclin infusions in 6 patients. CONCLUSION: A neoplastic origin of acral vascular syndrome should be considered in elderly patients, especially men, in the absence of usual causative conditions.
Language	eng
Pub Type(s)	Case Reports Journal Article Review
PubMed ID	12077580

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