| Title | [Biermer's disease and venous thrombosis. Report of two cases] | | Author(s) | Kharchafi A, Oualim Z, Amezyane T, Mahassin F, Ghafir D, Ohayon V, Archane MI | | Institution | Service de Médecine B, hôpital militaire d'instruction Mohammed V, Rabat, Maroc. azizkharchafi@yahoo.fr | | Source | Rev Med Interne 2002 Jun; 23(6):563-6. | | MeSH | Adult
Anemia, Pernicious
English Abstract
Humans
Hyperhomocysteinemia
Injections, Subcutaneous
Male
Risk Factors
Venous Thrombosis
Vitamin B 12
| | Abstract | INTRODUCTION: The main issue in venous thrombotic events is their etiology. Several clinical and/or biological data can be helpful in that research. In the two cases we report here, a macrocytic anemia led to the diagnosis of probably acquired hyperhomocysteinemia.
EXEGESIS: First case: a 24-year-old man was admitted for severe anemia and a superior vena cava syndrome. Biological data showed megaloblastic anemia and mild features of blood destruction that were explained by a pernicious anemia. Second case: a 35-year-old man had two deep venous thrombotic events in one year (involving the right leg, then the left leg); biological findings showed a macrocytic mild anemia that was diagnosed as a pernicious anemia. In both of the patients, deep venous thrombosis was mainly explained by a hyperhomocysteinemia that was a consequence of vitamin B12 deficiency. The two patients improved under anticoagulant treatment combined with subcutaneous vitamin B12.
CONCLUSION: Pernicious anemia can cause acquired hyperhomocysteinemia, which is considered a risk factor for deep venous thrombosis. Thus, the connectivity of these conditions should remain in the practitioner's mind, especially when thrombosis occurs along with a macrocytic anemia. | | Language | fre | | Pub Type(s) | Case Reports
Journal Article
| | PubMed ID | 12108182 |
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