Epidemiology of invasive group a streptococcus disease in the United States, 1995-1999. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. [Clin Infect Dis] Journal article

Title	Epidemiology of invasive group a streptococcus disease in the United States, 1995-1999.
Author(s)	O'Brien KL, Beall B, Barrett NL, Cieslak PR, Reingold A, Farley MM, Danila R, Zell ER, Facklam R, Schwartz B, Schuchat A
Institution	Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA. klobrien@jhsph.edu
Source	Clin Infect Dis 2002 Aug 1; 35(3):268-76.
MeSH	Antigens, Bacterial Bacterial Outer Membrane Proteins Carrier Proteins Humans Incidence Models, Statistical Population Surveillance Research Support, U.S. Gov't, P.H.S. Streptococcal Infections Streptococcal Vaccines Streptococcus pyogenes United States
Abstract	Severe invasive group A streptococcal (GAS) disease is believed to have reemerged during the past 10-20 years. We conducted active, laboratory, population-based surveillance in 5 US states (total population, 13,214,992). From 1 July 1995 through 31 December 1999, we identified 2002 episodes of invasive GAS (3.5 cases per 100,000 persons). Rates varied by age (higher among those <2 or >/=65 years old), surveillance area, and race (higher among black individuals) but did not increase during the study period. The 5 most common emm types (1, 28, 12, 3, and 11) accounted for 49.2% of isolates; newly characterized emm types accounted for 8.9% of isolates. Older age; presence of streptococcal toxic shock syndrome, meningitis, or pneumonia; and infection with emm1 or emm3 were all independent predictors of death. We estimate that 9600-9700 cases of invasive GAS disease occur in the United States each year, resulting in 1100-1300 deaths.
Language	eng
Pub Type(s)	Journal Article
PubMed ID	12115092

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