Aoyama H, Sakugawa H, Nakasone H, Nakayoshi T, Kinjo A, Tamayose M, Higa H, Uema E, Chinen T, Tomiyama R, Uchima N, Kugai Y, Kinjo F, Saito A, Kinjo M
A rare association of primary biliary cirrhosis and pernicious anemia. [Case Reports, Journal Article]
J Gastroenterol 2002; 37(7):560-3.
Primary biliary cirrhosis is often associated with autoimmune diseases. However, an association between primary biliary cirrhosis and pernicious anemia has rarely been reported. We report a patient with primary biliary cirrhosis associated with pernicious anemia and autoimmune gastritis. The patient was a 64-year-old Japanese woman who had been diagnosed as having primary biliary cirrhosis 5 years previously. She was readmitted with jaundice and macrocytic anemia. The diagnosis of pernicious anemia was confirmed by the low level of serum vitamin B12 and the presence of anti-parietal cell antibody and anti-intrinsic factor antibody. Pernicious anemia should be regarded as a possible complication of primary biliary cirrhosis.
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