Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae. Proceedings of the National Academy of Sciences of the United States of America. [Proc Natl Acad Sci U S A] Journal article

Title	Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae.
Author(s)	Tettelin H, Masignani V, Cieslewicz MJ, Eisen JA, Peterson S, Wessels MR, Paulsen IT, Nelson KE, Margarit I, Read TD, Madoff LC, Wolf AM, Beanan MJ, Brinkac LM, Daugherty SC, DeBoy RT, Durkin AS, Kolonay JF, Madupu R, Lewis MR, Radune D, Fedorova NB, Scanlan D, Khouri H, Mulligan S, Carty HA, Cline RT, Van Aken SE, Gill J, Scarselli M, Mora M, Iacobini ET, Brettoni C, Galli G, Mariani M, Vegni F, Maione D, Rinaudo D, Rappuoli R, Telford JL, Kasper DL, Grandi G, Fraser CM
Institution	The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
Source	Proc Natl Acad Sci U S A 2002 Sep 17; 99(19):12391-6.
MeSH	Amino Acid Sequence Comparative Study Evolution Genome, Bacterial Humans Molecular Sequence Data Oligonucleotide Array Sequence Analysis Phylogeny Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Serotyping Species Specificity Streptococcal Infections Streptococcus agalactiae Streptococcus pneumoniae Streptococcus pyogenes Virulence
Abstract	The 2,160,267 bp genome sequence of Streptococcus agalactiae, the leading cause of bacterial sepsis, pneumonia, and meningitis in neonates in the U.S. and Europe, is predicted to encode 2,175 genes. Genome comparisons among S. agalactiae, Streptococcus pneumoniae, Streptococcus pyogenes, and the other completely sequenced genomes identified genes specific to the streptococci and to S. agalactiae. These in silico analyses, combined with comparative genome hybridization experiments between the sequenced serotype V strain 2603 V/R and 19 S. agalactiae strains from several serotypes using whole-genome microarrays, revealed the genetic heterogeneity among S. agalactiae strains, even of the same serotype, and provided insights into the evolution of virulence mechanisms.
Language	eng
Pub Type(s)	Journal Article
PubMed ID	12200547

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