| Title | Effect of treatment by medicine or surgery on intraocular pressure and pulsatile ocular blood flow in normal-pressure glaucoma. | | Author(s) | Poinoosawmy D, Indar A, Bunce C, Garway-Heath DF, Hitchings RA | | Institution | Glaucoma Research Unit, Moorfields Eye Hospital, City Road, London, EC1V 2PD, UK. | | Source | Graefes Arch Clin Exp Ophthalmol 2002 Sep; 240(9):721-6. | | MeSH | Administration, Topical
Aged
Antihypertensive Agents
Betaxolol
Blood Flow Velocity
Comparative Study
Eye
Female
Glaucoma, Open-Angle
Humans
Intraocular Pressure
Male
Ophthalmic Solutions
Prostaglandins F, Synthetic
Pulsatile Flow
Quinoxalines
Retrospective Studies
Tonometry, Ocular
Trabeculectomy
| | Abstract | PURPOSE: To study the effect of trabeculectomy and monotherapy with topical betaxolol, brimonidine and latanoprost on intraocular pressure (IOP) and pulsatile ocular blood flow (POBF) in patients with normal-pressure glaucoma (NPG).
METHODS: In this retrospective study NPG patients attending the glaucoma research unit at Moorfields Eye Hospital were reviewed. Patients treated by surgery or topical medication (betaxolol, brimonidine or latanoprost) who had pre- and post-treatment IOP and POBF measurements were studied. For those patients who were having treatment to both eyes, one eye was selected at random for analysis.
RESULTS: A total of 147 patients were reviewed. Forty-three eyes were receiving betaxolol 0.5%, 58 eyes latanoprost 0.005%, 23 eyes brimonidine 0.2% and 23 eyes had undergone trabeculectomy surgery. There were more female than male patients in all four groups, and the groups were similar with regards age. Pre-treatment IOP and POBF values were similar among the groups ( P=0.27, P=0.08 respectively). Post-treatment IOP values tended to be lower than pre-treatment values for all four groups. All groups had an increased POBF except for betaxolol, where POBF decreased.
CONCLUSION: Patients treated by trabeculectomy and those receiving topical latanoprost and brimonidine had lower IOP and higher POBF following treatment. The betaxolol-treated group, despite a slight decrease in IOP, had a decreased POBF. Lowering IOP by treatment may not necessarily be associated with an increase in POBF. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 12271368 |
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