| Title | Echo-planar magnetic resonance imaging of Gaviscon alginate rafts in-vivo. | | Author(s) | Marciani L, Little SL, Snee J, Coleman NS, Tyler DJ, Sykes J, Jolliffe IG, Dettmar PW, Spiller RC, Gowland PA | | Institution | Magnetic Resonance Centre, School of Physics and Astronomy, Nottingham NG7 2RD, UK. | | Source | J Pharm Pharmacol 2002 Oct; 54(10):1351-6. | | MeSH | Adult
Alginates
Aluminum Hydroxide
Antacids
Chemistry, Physical
Contrast Media
Drug Combinations
Echo-Planar Imaging
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Research Support, Non-U.S. Gov't
Silicic Acid
Sodium Bicarbonate
Time Factors
| | Abstract | Liquid Gaviscon and Gaviscon Advance are established reflux suppressant formulations. This study describes the use of echo-planar magnetic resonance imaging (EPI) to visualise non-invasively intragastric alginate rafts of Liquid Gaviscon and Gaviscon Advance in healthy subjects. Secondly, the feasibility of using relaxation rate (T2(-1)) measurements to monitor changes in the physicochemical properties of the rafts in-vivo is evaluated. Six subjects ingested 500 mL of a liquid meal and received a single dose of 20 mL Liquid Gaviscon or 10 mL Gaviscon Advance on 2 separate visits each and were imaged every 15 min. An alginate raft was observed in the stomach for all subjects and both treatments. The raft was observed to consist of a few large fragments on the majority of the scans for both products. At t = 60 min a raft was still present in all cases. Three-dimensional volume reconstructions showed, for the first time, the spatial distribution of the rafts within the gastric lumen. The T2(-1) data showed potential for assessment of dynamic changes in the physicochemical properties of the alginate rafts in-vivo. We conclude that EPI shows great potential in assessing alginate rafts formation in-vivo. | | Language | eng | | Pub Type(s) | Clinical Trial
Journal Article
Randomized Controlled Trial
| | PubMed ID | 12396296 |
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