Myoglobin, creatine kinase MB isoforms and creatine kinase MB mass in early diagnosis of myocardial infarction in patients with acute chest pain. Clinical biochemistry. [Clin Biochem] Journal article | | Title | Myoglobin, creatine kinase MB isoforms and creatine kinase MB mass in early diagnosis of myocardial infarction in patients with acute chest pain. | | Author(s) | Penttilä K, Koukkunen H, Halinen M, Rantanen T, Pyörälä K, Punnonen K, Penttilä I | | Institution | Department of Clinical Chemistry, Kuopio University Hospital, Kuopio, Finland. karri.penttila@kuh.fi | | Source | Clin Biochem 2002 Nov; 35(8):647-53. | | MeSH | Aged
Biological Markers
Creatine Kinase
Creatine Kinase, MB Form
Female
Humans
Isoenzymes
Male
Myocardial Infarction
Myoglobin
Protein Isoforms
ROC Curve
Troponin T
| | Abstract | OBJECTIVES: Measurements of myoglobin and creatine kinase (CK)-MB isoforms have been suggested to be sensitive tests for the early diagnosis of myocardial infarction (MI). We have investigated the utility of myoglobin, creatine kinase (CK)-MB isoforms and creatine kinase MB mass (CK-MBm) in early diagnosis of MI using cardiac troponin T (cTnT) positivity as a reference.
DESIGN AND METHODS: The study population comprised 440 patients who had had chest pain for less than 12 h. Patients were divided into cTnT negative (cTnT-) or cTnT positive (cTnT+) patients (concentration of cTnT >0.1 microg/L at two different time points during 72 h).
RESULTS: At the time of admission to the emergency department receiver operating characteristics (ROC) curves of CK-MB isoforms and CK-MBm were not better than that of myoglobin. Six hours after admission CK-MB isoforms and CK-MBm provided statistically significantly larger areas under the curve (AUC) than myoglobin (p < 0.01). When ROC curves were related to the onset of chest pain (< 3 h, 3-6 h, and > 6 h) there were no significant differences between the cardiac markers studied.
CONCLUSIONS: According to the present findings, CK-MB isoforms or myoglobin offer no advantage over CK-MBm as early markers of myocardial infarction. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 12499000 |
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