| Title | Factor XIII and tissue transglutaminase antibodies in coeliac and inflammatory bowel disease. | | Author(s) | Sjöber K, Eriksson S, Tenngart B, Roth EB, Leffler H, Stenberg P | | Institution | Department of Medicine, Lund University, University Hospital, SE-205 02 Malmö, Sweden. klas.sjoberg@medforsk.mas.lu.se | | Source | Autoimmunity 2002 Aug; 35(5):357-64. | | MeSH | Adult
Aged
Aged, 80 and over
Antibody Specificity
Autoantibodies
Case-Control Studies
Celiac Disease
Colitis, Ulcerative
Crohn Disease
Cross Reactions
Factor XIII
Female
GTP-Binding Proteins
Humans
Immunoglobulin A
Immunoglobulin G
Male
Middle Aged
Research Support, Non-U.S. Gov't
Transglutaminases
| | Abstract | Tissue transglutaminase (tTg) has been identified as an autoantigen in coeliac disease (CD). There is a marked homology between different forms of transglutaminase, such as tTg and coagulation factor XIII. We compared titres of both IgA- and IgG-antibodies against these two antigens in 20 CD patients, 20 endomysial antibody (EMA)-negative controls and a group with inflammatory bowel disease (34 with Crohn's disease and 23 with ulcerative colitis). IgA-antibodies against tTg correlated with EMA titres and had high sensitivity and specificity in screening for CD. Only in two CD patients were high titres found of IgA-antibodies against factor XIII, non-reactive with tTg. Both lacked bleeding tendency. The presence of IgG-antibodies against tTg, in contrast, had low sensitivity and specificity in screening for CD and were frequently seen in inflammatory bowel disease. Similarly, factor XIII IgG-antibodies displayed a non-specific pattern with modestly elevated titres in patients with Crohn's disease and in both EMA-negative and positive patients. Despite a marked homology with tTg, the occurrence of high titre IgA-antibodies against factor XIII is infrequent in CD, but may-when present-be the result of epitope spreading. The presence of IgG-antibodies in CD and inflammatory bowel disease illustrates the complexity of autoantibody reactions in gastrointestinal disease. | | Language | eng | | Pub Type(s) | Case Reports
Journal Article
| | PubMed ID | 12515290 |
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