Overview of existing research and information linking isotretinoin (accutane), depression, psychosis, and suicide. American journal of therapeutics. [Am J Ther] Journal article | | Title | Overview of existing research and information linking isotretinoin (accutane), depression, psychosis, and suicide. | | Author(s) | O'Donnell J | | Institution | Department of Pharmacology, Rush Medical College, Chicago, Illinois, USA. JODONN1935@aol.com | | Source | Am J Ther 2003 Mar-Apr; 10(2):148-59. | | MeSH | Acne Vulgaris
Adverse Drug Reaction Reporting Systems
Affect
Depression
Dermatologic Agents
Humans
Isotretinoin
Psychoses, Substance-Induced
Risk Factors
Suicide, Attempted
United States
United States Food and Drug Administration
| | Abstract | Isotretinoin (Accutane; Hoffmann-La Roche, Nutley, NJ) is a drug closely related to the chemical structure of vitamin A. The pharmacology and toxicology of these two retinoids are similar enough to warrant comparison. Accutane is a powerful drug that its manufacturer, Roche, indicates is limited for severe recalcitrant nodular acne. This potency is also reflected in Accutane's well-known ability to produce severe birth defects if taken during pregnancy. Less well known is the risk of this lipid-soluble chemical to affect the central nervous system. Reports of intracranial hypertension, depression, and suicidal ideation with Accutane use have prompted an examination of its serious and life-threatening potential. Although Roche has added a warning to its product label for signs of depression, and suicidal ideation, this product is overprescribed for all forms of acne, including mild and moderate cases that have not been treated with alternative medications with less risk of depression and suicide. There is no contesting that this drug is effective at clearing up the most severe forms of acne, but the public must be informed of the proper limited indication for its use, because depression and suicide can follow in patients with no prior history of psychiatric symptoms or suicide attempts. | | Language | eng | | Pub Type(s) | Case Reports
Journal Article
Review
| | PubMed ID | 12629595 |
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