| Title | Beta-amyloid precursor protein staining in nonhomicidal pediatric medicolegal autopsies. | | Author(s) | Reichard RR, White CL, Hladik CL, Dolinak D | | Institution | Neuropathology Laboratory, University of Texas Southwestern Medical School, Department of Pathology, Dallas, Texas, USA. Ross@ud.net | | Source | J Neuropathol Exp Neurol 2003 Mar; 62(3):237-47. | | MeSH | Amyloid beta-Protein Precursor
Autopsy
Brain
Child
Child, Preschool
Humans
Infant
Infant, Newborn
Prospective Studies
Spinal Cord
Staining and Labeling
| | Abstract | Immunohistochemical staining for beta-amyloid precursor protein (betaAPP) has been validated as a marker for axonal injury in adults surviving > or = 2 hours after white matter damage. The significance of betaAPP staining in pediatric brains and spinal cords is not as well established. We evaluated the white matter immunoreactivity for betaAPP from a variety of pediatric medicolegal autopsies: natural disease (non-Sudden Infant Death Syndrome [SIDS]), SIDS, motor vehicle accidents, drowning, near-drowning, overlay, carbon monoxide toxicity, miscellaneous trauma, and mechanical asphyxia. The cases of carbon monoxide toxicity, motor vehicle accidents (death at scene), drowning (with resuscitation), and a natural (non-SIDS) death had no significant white matter staining. The traumatic deaths with a significant survival interval, a variety of natural deaths, the near-drowning case, and surprisingly, all SIDS had detectable betaAPP white matter immunostaining. These results demonstrate that features other than traumatic axonal injury, such as metabolic insults and hypoxic-ischemic injury secondary to vascular compromise, must contribute to betaAPP immunostaining. In addition, we describe a variety of betaAPP-immunoreactive structures not previously reported in the pediatric population. This study illustrates that betaAPP immunostaining enhances detection of a variety of white matter changes, and provides a basis for interpretation of these results. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 12638728 |
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