Biswas AK, Zabrocki LA, Mayes KL, Morris-Kukoski CL
Cardiotoxicity associated with intentional ziprasidone and bupropion overdose. [Case Reports, Journal Article]
J Toxicol Clin Toxicol 2003; 41(1):79-82.
BACKGROUND: Ziprasidone (Geodon) and bupropion (Wellbutrin) are medications prescribed for mood and behavior disorders. They have apparently safe cardiac safety profiles in both therapeutic and supra-therapeutic doses.
CASE REPORT: A 17-year-old male developed a widened QRS and a prolonged QTc interval following an overdose of ziprasidone and bupropion. He required hospital admission for aggressive cardiac monitoring and antidysrhythmic therapy, stabilizing to baseline by 80 hours post-ingestion.
CONCLUSIONS: We present a case that underscores the potential cardiotoxicities of these medications. Ziprasidone and bupropion ingestion can be associated with cardiotoxicities that may require several days of aggressive cardiac monitoring and treatment.
More from this journalRelated subjects (MeSH) |
