| Title | Cardiotoxicity associated with intentional ziprasidone and bupropion overdose. |
| Author(s) | Biswas AK, Zabrocki LA, Mayes KL, Morris-Kukoski CL |
| Institution | Pediatric Critical Care Medicine, Naval Medical Center Portsmouth, Portsmouth, Virginia 23708, USA. akbiswas@mar.med.navy.mil |
| Source | J Toxicol Clin Toxicol 2003; 41(1):79-82. |
| MeSH | Adult
Anti-Arrhythmia Agents
Antidepressive Agents, Second-Generation
Antipsychotic Agents
Bupropion
Electrocardiography
Heart Diseases
Humans
Hydrogen-Ion Concentration
Long QT Syndrome
Male
Overdose
Piperazines
Suicide, Attempted
Thiazoles
|
| Abstract | BACKGROUND: Ziprasidone (Geodon) and bupropion (Wellbutrin) are medications prescribed for mood and behavior disorders. They have apparently safe cardiac safety profiles in both therapeutic and supra-therapeutic doses.
CASE REPORT: A 17-year-old male developed a widened QRS and a prolonged QTc interval following an overdose of ziprasidone and bupropion. He required hospital admission for aggressive cardiac monitoring and antidysrhythmic therapy, stabilizing to baseline by 80 hours post-ingestion.
CONCLUSIONS: We present a case that underscores the potential cardiotoxicities of these medications. Ziprasidone and bupropion ingestion can be associated with cardiotoxicities that may require several days of aggressive cardiac monitoring and treatment. |
| Language | eng |
| Pub Type(s) | Case Reports
Journal Article
|
| PubMed ID | 12645973 |
