Soft tissue augmentation with artecoll: 10-year history, indications, techniques, and complications. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. [Dermatol Surg] Journal article

Title	Soft tissue augmentation with artecoll: 10-year history, indications, techniques, and complications.
Author(s)	Lemperle G, Romano JJ, Busso M
Institution	Division of Plastic Surgery, University of California, San Diego, USA. glemperle@aol.com
Source	Dermatol Surg 2003 Jun; 29(6):573-87; discussion 587.
MeSH	Biocompatible Materials Cicatrix Collagen Cosmetic Techniques Face Humans Injections, Intradermal Microspheres Patient Selection Polymethyl Methacrylate Reconstructive Surgical Procedures Skin Aging
Abstract	Most of the biologic filler materials that increase the thickness of the corium in a wrinkle line are phagocytosed within a certain time. Therefore, a lasting effect can only be achieved with nonresorbable synthetic substances. Artefill consists of 20 volume percent microspheres of polymethyl-methacrylate and 80 volume percent of bovine collagen. Beneath the crease, the microspheres with their exceptional surface smoothness stimulate fibroblasts to encapsulate each individual one of the 6-million microspheres contained in 1 mL of Artefill. Collagen is merely a carrier substance that prevents the microspheres from agglomerating during tissue ingrowth. The 20 volume percent of microspheres in Artefill provides the scaffold for the 80% volume of connective tissue deposition, a complete replacement of the injected collagen. The filler material beneath a crease acts like a splint and prevents the possibility of its further folding, thereby allowing the diminished thickness of the corium in a crease to recover. This recovery process is well known even in older patients with facial paralysis or after a stroke, whose facial wrinkles and furrows on the paralyzed side disappear over time.
Language	eng
Pub Type(s)	Journal Article Review
PubMed ID	12786699

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