| Title | Diphenhydramine-induced wide complex dysrhythmia responds to treatment with sodium bicarbonate. | | Author(s) | Sharma AN, Hexdall AH, Chang EK, Nelson LS, Hoffman RS | | Institution | New York City Poison Control Center, New York, NY, USA. ansharma@pol.net | | Source | Am J Emerg Med 2003 May; 21(3):212-5. | | MeSH | Acetaminophen
Adult
Arrhythmia
Aspirin
Diphenhydramine
Drug Combinations
Drugs, Non-Prescription
Fatal Outcome
Female
Humans
Hypertonic Solutions
Hypnotics and Sedatives
Infusions, Intravenous
Male
Methapyrilene
Salicylamides
Sodium Bicarbonate
Suicide, Attempted
Treatment Outcome
| | Abstract | Diphenhydramine, a common ingredient in over-the-counter medications, is often taken in overdose. Toxicity is usually limited to anticholinergic symptoms. However, because diphenhydramine also exhibits type IA sodium channel blockade, cardiac toxicity is also possible. Although it would be expected that, like other type IA toxicities, diphenhydramine-induced cardiotoxicity could be responsive to hypertonic sodium bicarbonate, this finding is largely unappreciated. We describe 3 cases of diphenhydramine-induced cardiac toxicity that were responsive to bicarbonate. | | Language | eng | | Pub Type(s) | Case Reports
Journal Article
| | PubMed ID | 12811715 |
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