[Actinic keratoses] Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete. [Hautarzt] Journal article

Title	[Actinic keratoses]
Author(s)	Babilas P, Landthaler M, Szeimies RM
Institution	Klinik und Poliklinik für Dermatologie, Klinikum der Universität Regensburg.
Source	Hautarzt 2003 Jun; 54(6):551-60; quiz 561-2.
MeSH	Adult Age Factors Aged Biopsy Carcinoma, Squamous Cell Combined Modality Therapy Comparative Study Diagnosis, Differential English Abstract Female Genes, p53 Hand Dermatoses Humans Keratosis Male Middle Aged Multicenter Studies Mutation Neoplasm Invasiveness Photosensitivity Disorders Physical Therapy Modalities Prevalence Risk Factors Scalp Dermatoses Skin Skin Neoplasms Telomerase Terminology Ultraviolet Rays
Abstract	Actinic keratoses are defined as proliferation of cytologically atypical keratinocytes in the zone of epidermal-dermal junction in photodamaged skin. In the northern hemisphere the prevalence of actinic keratoses ranges depending on different epidemiological studies from 11% to 25% for people aged 40 or older. The main cause of actinic keratoses is exposure to UVB radiation in sunlight UVB radiation induces mutations in the telomerase gene and in the tumor suppressor gene P53, which can also be detected in invasive squamous cell carcinoma. The only histological parameter to distinguish between actinic keratoses and SCC is the level of invasiveness. The risk for actinic keratoses to develop into SCC is about 16% over lo years. For this reason and because of the high prevalence of actinic keratoses, it has been suggested to replace the term,, actinic keratosis K with intraepidermal squamous cell carcinoma' to better characterize the lesion. In the following review recent aspects of pathogenesis and therapy of actinic keratoses are discussed.
Language	ger
Pub Type(s)	Journal Article Review
PubMed ID	12858853

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