| Title | Metformin and gestational diabetes. | | Author(s) | Glueck CJ, Goldenberg N, Streicher P, Wang P | | Institution | Jewish Hospital Cholesterol Center, ABC Building, 3200 Burnet Avenue, Cincinnati, OH 45229, USA. glueckch@healthall.com | | Source | Curr Diab Rep 2003 Aug; 3(4):303-12. | | MeSH | Clinical Trials
Diabetes Mellitus, Type 2
Diabetes, Gestational
Female
Glucose
Humans
Hypoglycemic Agents
Insulin
Insulin Resistance
Islets of Langerhans
Mass Screening
Metformin
Polycystic Ovary Syndrome
Pregnancy
Research Support, Non-U.S. Gov't
| | Abstract | Pregnancy increases requirements for insulin secretion, increasing insulin resistance and demands on pancreatic b cells, promoting development of gestational diabetes (GD), particularly in women with preexisting insulin resistance, commonly in women with polycystic ovary syndrome. Preliminary studies suggest that metformin may have the unique potential to prevent the development of GD. We postulate that interventions that reduce insulin resistance and lower requirements for endogenous insulin secretion can preserve b-cell function and prevent the development of type 2 diabetes mellitus. | | Language | eng | | Pub Type(s) | Journal Article
Review
| | PubMed ID | 12866993 |
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