Effect of single dose of diuretics on renal magnesium excretion in man, with special reference to their site of action. Physiologia Bohemoslovaca [Physiol Bohemoslov] Journal article | | Title | Effect of single dose of diuretics on renal magnesium excretion in man, with special reference to their site of action. | | Author(s) | Sotorník I, Schück O | | Source | Physiol Bohemoslov 1976; 25(3):207-12. | | MeSH | Adult
Creatinine
Diuresis
Diuretics
Ethacrynic Acid
Female
Furosemide
Humans
Magnesium
Male
Mannitol
Osmolar Concentration
Polythiazide
Potassium
Sodium
Urine
| | Abstract | The administration of a single dose of furosemide, ethacrynic acid and polythiazide to healthy individuals under conditions of maximum water diuresis produces a significant increase in renal magnesium excretion. Elevated Mg excretion displayed a direct correlation to renal sodium excretion after furosemide (r=0.689, p less than 0.001), ethacrynic acid (r=0.869, p less than 0.001) and polythiazide (r=0.586, p less than 0.01). The slopes of the various regression lines did not differe significantly from each other or from the slope of the regression line characterizing this correlation for mannitol (r= 0.603, p less than 0.01). A significant linear correlation was likewise found between the excretion of Mg and total osmotically active substances after furosemide (r=0.783, p less than 0.001), ethacrynic acid (r=0.88, p less than 0.001) and polythiazide (r=0.646, p less than 0.01). The regression lines of the given correlations did not differ significantlyfrom each other, but their slopes were significantly higher than that of the regression line for the correlation after mannitol (r=0.454, p less than 0.01). The findings indicate that tubular Mg transport is influenced both by a decrease in tubular Na resorption in the diluting segment (polythiazide) and by an effect on Na resorption in the parts of the nephron proximal to the diluting segment of the nephron (furosemide, ethacrynic acid). | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 133359 |
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