| Title | A comparison of gastro-oesophageal reflux in volunteers assessed by ambulatory pH and gamma monitoring after treatment with either Liquid Gaviscon or Algicon Suspension. | | Author(s) | Washington N, Greaves JL, Iftikhar SY | | Institution | Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham, UK. | | Source | Aliment Pharmacol Ther 1992 Oct; 6(5):579-88. | | MeSH | Adult
Alginates
Aluminum Hydroxide
Ambulatory Care
Antacids
Bicarbonates
Calibration
Carbonates
Comparative Study
Drug Combinations
Electrodes, Implanted
Esophagus
Female
Food
Gamma Cameras
Gastroesophageal Reflux
Humans
Hydrogen-Ion Concentration
Male
Monitoring, Physiologic
Research Support, Non-U.S. Gov't
Silicic Acid
Sodium Bicarbonate
Technetium
| | Abstract | This study was designed to compare the effectiveness of single doses of either Liquid Gaviscon or Algicon Suspension in the suppression of food and acid reflux into the oesophagus after a test meal in volunteers. After the pH electrode and gamma detector were positioned 5 cm above the cardia, the volunteers received a refluxogenic radiolabelled meal. The subjects then remained untreated, or thirty minutes later they were given a dose of unlabelled Algicon Suspension, or Liquid Gaviscon and a recording was made for a minimum of 3 hours. Allocation to the treatment group was randomized with the cross-overs performed 1 week apart. Liquid Gaviscon suppressed gastro-oesophageal reflux of both food and acid whereas only an insignificant reduction in reflux was seen after Algicon Suspension. The oesophageal pH remained below 4 for 3.21 +/- 0.92% (S.E.M.) of the recording period in the control study, 0.88 +/- 0.33 after Gaviscon and 2.91 +/- 0.68 after Algicon. The reflux of food was reduced from 17,070 x 10(3) +/- 4713 x 10(3) counts in the control study to 224 x 10(3) +/- 93 x 10(3) counts after the Gaviscon and 16,080 x 10(3) +/- 7131 x 10(3) counts after Algicon. The suppression of reflux by Liquid Gaviscon was significantly better than that produced by Algicon Suspension. | | Language | eng | | Pub Type(s) | Clinical Trial
Journal Article
Randomized Controlled Trial
| | PubMed ID | 1420749 |
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