Hannequin JR
Efficacy of Arthrotec in the treatment of rheumatoid arthritis. [Clinical Trial, Journal Article, Randomized Controlled Trial]
Scand J Rheumatol Suppl 1992.:7-14.
In a double-blind study, 346 patients with active rheumatoid arthritis were randomly assigned to receive Arthrotec, a combination of 50 mg of diclofenac and 200 *g of misoprostol, or 50 mg of diclofenac; the drugs were given two or three times daily for 12 weeks. At weeks 4, 8, and 12 of treatment, no clinically significant differences between the two treatment groups were noted on measures of joint tenderness, pain, and swelling or on physicians' and patients' assessments of disease severity.
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