| Title | A pharmacokinetic/pharmacodynamic study comparing a single morning dose of adderall to twice-daily dosing in children with ADHD. | | Author(s) | Greenhill LL, Swanson JM, Steinhoff K, Fried J, Posner K, Lerner M, Wigal S, Clausen SB, Zhang Y, Tulloch S | | Institution | Attention Deficit Disorder Research Program, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA. LarryLGreenhill@cs.com | | Source | J Am Acad Child Adolesc Psychiatry 2003 Oct; 42(10):1234-41. | | MeSH | Administration, Oral
Amphetamines
Attention Deficit Disorder with Hyperactivity
Central Nervous System Stimulants
Child
Comparative Study
Female
Humans
Male
Research Support, Non-U.S. Gov't
| | Abstract | OBJECTIVE: To determine the pharmacokinetic and pharmacodynamic properties of once-daily versus twice-daily doses of Adderall.
METHOD: Following a 1-week wash-out, 12 subjects with attention-deficit/hyperactivity disorder (ADHD) entered a double-blind crossover study comparing two conditions: QD (10 mg of Adderall at 7:30 a.m. and placebo at noon) or BID (10 mg of Adderall at 7:30 a.m. and at noon). At two sites, cohorts of six subjects each were assessed on two different days by a 12-hour laboratory school protocol. Plasma concentrations of d- and l-amphetamine, vital signs, teacher ratings of classroom behavior on the SKAMP, and 10-minute Math Test performance were measured repeatedly over 12 hours. An analysis of variance used center, subject-within-center, condition, and time-after-second-dose as independent variables.
RESULTS: The pharmacokinetic profiles revealed similar morning concentrations of d- and l-amphetamine. However, concentrations were twice as high in the afternoon for BID as QD. The two conditions showed similar pharmacodynamic profiles in the morning, although improvement in math performance and behavior was maintained into the afternoon only in the BID condition (p <.05).
CONCLUSIONS: This study suggests that twice-daily dosing of Adderall may be an effective strategy for afternoon control of attention and deportment for children with ADHD. | | Language | eng | | Pub Type(s) | Clinical Trial
Journal Article
Multicenter Study
| | PubMed ID | 14560174 |
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