Effects of alatrofloxacin, the parental prodrug of trovafloxacin, on phagocytic, anti-inflammatory and immunomodulation events of human THP-1 monocytes. Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie. [Biomed Pharmacother] Journal article | | Title | Effects of alatrofloxacin, the parental prodrug of trovafloxacin, on phagocytic, anti-inflammatory and immunomodulation events of human THP-1 monocytes. | | Author(s) | Hall IH, Schwab UE, Ward ES, Ives TJ | | Institution | Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, NC Chapel Hill 27559-7360, USA. iris_hall@unc.edu | | Source | Biomed Pharmacother 2003 Oct; 57(8):359-65. | | MeSH | Adjuvants, Immunologic
Anti-Inflammatory Agents
Cell Line
Cytokines
Fluoroquinolones
Humans
Monocytes
Naphthyridines
Phagocytosis
Prodrugs
Staphylococcus aureus
Superoxide Dismutase
Time Factors
| | Abstract | Alatrofloxacin functions similar to other fluoroquinolone antibiotics in that it not only has antibiotic activity to kill invading organisms by interfering with DNA synthesis, it possesses immunosuppressive activity. In the first hour after bacteria have been phagocytosed by THP-1 monocytes, the drug activates a lytic mechanism involving the release of c-AMP, tumor necrosis factor (TNFalpha), interleukin-1 (IL-1), IL-6 and nitric oxide, with elevations in lysosomal hydrolytic enzyme activities. This effect reverses between 2 and 4 h. At this time, all of these inflammatory processes are returned to normal values or below suggesting that alatrofloxacin reduces the spread of infection and destruction of tissue related to inflammation. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 14568230 |
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