| Title | [Genetic determinants of hereditary thrombophilia in pathogenesis of venous thrombosis] | | Author(s) | Kapustin SI, Blinov MN, Kargin VD, Filanovskaia LI, Saltykova NB, Beliazo OE, Golovina OG, Shmeleva VM, Panshina AM, Papaian LP | | Source | Ter Arkh 2003; 75(10):78-80. | | MeSH | Adolescent
Adult
Aged
Factor V
Female
Genetic Predisposition to Disease
Humans
Leukocytes
Male
Methylenetetrahydrofolate Reductase (NADPH2)
Middle Aged
Mutation
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Prothrombin
Risk Factors
Thrombophilia
Venous Thrombosis
| | Abstract | AIM: To study the role of genetic determinants of hereditary thrombophilia in pathogenesis of various clinical manifestations of venous thrombosis in the citizens of the North-West Region of Russia.
MATERIAL AND METHODS: Mutations of the genes of factor V (FV Leiden), prothrombin (G20210-A) and polymorphism C677-T in the gene of methylentetrahydrofolate reductase (MTHFR) were detected using polymerase chain reaction (PCR) with a following restriction analysis of PCR product in 183 patients with venous thrombosis (115 with isolated thrombosis of the deep veins and 68 with thromboembolism of the pulmonary artery).
RESULTS: It was established that mutation FV Leiden is a significant risk factor of deep vein thrombosis in the legs and postthrombotic disease, but this mutation is weakly associated with pulmonary artery thromboembolism (PAT). An essential PAT risk factor is carriage of the variant prothrombin G20210A.
CONCLUSION: Determination of prothrombotic genotypes is a key factor of treatment efficacy and prevention of life-threatening thromboembolic complications. | | Language | rus | | Pub Type(s) | English Abstract
Journal Article
| | PubMed ID | 14669613 |
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