| Title | Oral clodronate therapy for hypercalcemia related to extensive subcutaneous fat necrosis in a newborn. | | Author(s) | Hung SH, Tsai WY, Tsao PN, Chou HC, Hsieh WS | | Institution | Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. | | Source | J Formos Med Assoc 2003 Nov; 102(11):801-4. | | MeSH | Administration, Oral
Antimetabolites
Clodronic Acid
Fat Necrosis
Female
Humans
Hypercalcemia
Infant, Newborn
| | Abstract | Hypercalcemia is occasionally found in newborns with subcutaneous fat necrosis and carries potential life-threatening risk. Bisphosphonates have been recently introduced in the treatment of subcutaneous fat necrosis in newborns. We report a case of extensive subcutaneous fat necrosis in a female infant complicated with intractable hypercalcemia. Standard treatment for hypercalcemia was given, including saline hydration, a low calcium diet, furosemide, and glucocorticoid, but without response. Serum 1,25-dihydroxyvitamin D level was elevated at 126 pg/mL, 25-hydroxyvitamin D level was normal, and intact parathyroid hormone was suppressed at < 1 pg/mL. Oral clodronate disodium, a second-generation bisphosphonate, was administered, and resulted in the normalization of serum calcium, urine N-telopeptide, urine calcium/creatinine ratio, and serum intact parathyroid hormone level. This case suggests that oral clodronate may be an effective treatment for subcutaneous fat necrosis with hypercalcemia in newborns. | | Language | eng | | Pub Type(s) | Case Reports
Journal Article
| | PubMed ID | 14724728 |
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