| Title | The Ginkgo biloba extract (EGb 761) provides a neuroprotective effect on retinal ganglion cells in a rat model of chronic glaucoma. | | Author(s) | Hirooka K, Tokuda M, Miyamoto O, Itano T, Baba T, Shiraga F | | Institution | Department of Ophthalmology, Kagawa University School of Medicine, Miki, Kagawa, Japan. kazuyk@kms.ac.jp | | Source | Curr Eye Res 2004 Mar; 28(3):153-7. | | MeSH | Animals
Cell Count
Chronic Disease
Disease Models, Animal
Female
Ginkgo biloba
Glaucoma
Intraocular Pressure
Neuroprotective Agents
Ocular Hypertension
Plant Extracts
Rats
Rats, Sprague-Dawley
Retinal Ganglion Cells
| | Abstract | PURPOSE: To investigate the effect of Ginkgo biloba extract (EGb 761) against neurotoxicity of retinal ganglion cells of rats with chronic moderately elevated intraocular pressure (IOP).
METHODS: Unilateral chronic moderately elevated IOP was produced in rats by cautery of three episcleral vessels. Secondary degeneration was measured with and without EGb 761 for 5 months. At 5 months, retinal ganglion cells were labeled with a fast blue tracer applied to both superior colliculi. Densities of surviving retinal ganglion cells were estimated by counting fast blue labeled cells in whole mounted retinas.
RESULTS: When compared with their contralateral control eyes with normal IOP, in the peripheral retina, retinal ganglion cell loss in eyes with chronic, moderately elevated IOP was 29.8 +/- 1.5% (n=5) at 5 months in untreated animals and 4.6 +/- 4.5% (n=5) at 5 months in treated animals with EGb 761.
CONCLUSIONS: Pretreatment and early posttreatment with EGb 761 is an effective neuroprotectant in a rat model of chronic glaucoma. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 14977516 |
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