| Title | Influence of vitamins and iron on plasma fluoride levels in rats. | | Author(s) | Chan JT, Stark CM, Wild TW, Jeske AH | | Institution | University of Texas Dental Branch, Houston. | | Source | Pediatr Dent 1992 Jan-Feb; 14(1):37-40. | | MeSH | Animals
Biological Availability
Drug Combinations
Drug Interactions
Female
Fluorides
Iron
Rats
Rats, Inbred Strains
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Vitamins
| | Abstract | Thirty female Sprague-Dawley rats (250 +/- 10 g) were divided randomly into five equal groups. After overnight fasting, a silastic catheter was placed in the jugular vein of each rat. Each group was intragastrically administered 0.25 mg F/250 g rat weight in 1 ml of one of the following forms of fluoride supplements: Pediaflor (Abbott/Ross, Columbus, OH), Tri-Vi-Flor, Tri-Vi-Flor + iron; Poly-Vi-Flor or Poly-Vi-Flor + iron (Mead Johnson Nutritionals, Bristol-Myers Squibb Co., Evansville, IN). Timed blood samples were collected and plasma fluoride concentration was determined using the microdiffusion method. The presence of iron and vitamins affect the bioavailability of fluoride as measured by the area under the time-plasma fluoride concentration curve. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 1502114 |
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