| Title | Alpha-tocopherol and alpha-tocopheryl quinone levels in cervical intraepithelial neoplasia and cervical cancer. | | Author(s) | Palan PR, Woodall AL, Anderson PS, Mikhail MS | | Institution | Department of Obstetrics and Gynecology, Bronx-Lebanon Hospital Center, and Albert Einstein College of Medicine, Bronx, NY, USA. | | Source | Am J Obstet Gynecol 2004 May; 190(5):1407-10. | | MeSH | Adult
Aged
Cervical Intraepithelial Neoplasia
Colposcopy
Comparative Study
Cross-Sectional Studies
Female
Humans
Middle Aged
Oxidative Stress
Probability
Prognosis
Reference Values
Sensitivity and Specificity
Tumor Markers, Biological
Uterine Cervical Neoplasms
Vaginal Smears
Vitamin E
alpha-Tocopherol
| | Abstract | OBJECTIVE: alpha-Tocopherol is a potent antioxidant that protects cell membranes against oxidative damage. Red blood cell alpha-tocopherol levels reflect membrane alpha-tocopherol concentrations, and altered levels may suggest membrane damage. The objective of this study was to determine the levels of alpha-tocopherol and alpha-tocopheryl quinone, the oxidized product of alpha-tocopherol, in plasma and red blood cells that were obtained from control subjects and patients with cervical intraepithelial neoplasia and cervical cancer.
STUDY DESIGN: In this cross-sectional study, 72 women, (32 African American and 40 Hispanic) were recruited. Among these subjects, 37 women had cervical intraepithelial neoplasia; 14 women had cervical cancer, and 21 women were considered control subjects, who had normal Papanicolaou test results. alpha-Tocopherol and alpha-tocopheryl quinone levels were determined in red blood cell and plasma by high-pressure liquid chromatography.
RESULTS: Plasma levels of alpha-tocopherol and alpha-tocopheryl quinone were decreased significantly (P=.012 and=.005, respectively, by Kruskal-Wallis test) in study groups compared with the control group; red blood cell levels of alpha-tocopherol and alpha-tocopheryl quinone were not altered significantly.
CONCLUSION: The lower alpha-tocopherol level that was observed in this study is consistent with our previous reports of decreased antioxidant concentrations and increased oxidative stress in women with cervical intraepithelial neoplasia. Unaltered red blood cell alpha-tocopherol and alpha-tocopheryl quinone levels suggest undamaged cell membrane. Further studies are needed to investigate the potential role of oxidative stress in cervical intraepithelial neoplasia. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 15167851 |
|
