| Title | Aspirin and NSAID sensitivity. | | Author(s) | Stevenson DD | | Institution | Division of Allergy, Asthma, and Immunology, Department of Medicine, Scripps Clinic and The Scripps Research Institute, W 205, 10666 North Torrey Pines Road, La Jolla, CA 92037, USA. stevensn@scripps.edu | | Source | Immunol Allergy Clin North Am 2004 Aug; 24(3):491-505, vii. | | MeSH | Anti-Inflammatory Agents, Non-Steroidal
Aspirin
Cyclooxygenase 1
Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors
Desensitization, Immunologic
Drug Hypersensitivity
Humans
Isoenzymes
Membrane Proteins
Prostaglandin-Endoperoxide Synthases
Research Support, Non-U.S. Gov't
| | Abstract | Aspirin and the older nonsteroidal anti-inflammatory drugs (NSAIDs) that block cyclo-oxygenase-1 (COX-1) induce asthma attacks in patients with aspirin-exacerbated respiratory disease and urticaria in patients with chronic idiopathic urticaria. Weak inhibitors of COX-1, such as acetaminophen and salsalate, crossreact also but only with high doses of the drugs. Partial inhibitors of both COX-1 and COX-2, such as nimesulide and meloxicam, also cross-react but only at high drug doses. COX-2 inhibitors do not cross-react; however, all NSAIDs, including the selective COX-2 inhibitors, can sensitize patients and induce urticaria or anaphylaxis on next exposure to the drug. | | Language | eng | | Pub Type(s) | Journal Article
Review
| | PubMed ID | 15242723 |
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