Factors influencing local relapse and survival and results of salvage treatment after breast-conserving therapy in operable breast cancer: EORTC trial 10801, breast conservation compared with mastectomy in TNM stage I and II breast cancer. European journal of cancer (Oxford, England : 1990) [Eur J Cancer] Journal article | | Title | Factors influencing local relapse and survival and results of salvage treatment after breast-conserving therapy in operable breast cancer: EORTC trial 10801, breast conservation compared with mastectomy in TNM stage I and II breast cancer. | | Author(s) | van Dongen JA, Bartelink H, Fentiman IS, Lerut T, Mignolet F, Olthuis G, van der Schueren E, Sylvester R, Tong D, Winter J | | Institution | Department of Surgery, The Netherlands Cancer Institute, Amsterdam. | | Source | Eur J Cancer 1992; 28A(4-5):801-5. | | MeSH | Aging
Breast Neoplasms
Combined Modality Therapy
Female
Follow-Up Studies
Humans
Incidence
Mastectomy, Modified Radical
Mastectomy, Segmental
Middle Aged
Neoplasm Metastasis
Neoplasm Recurrence, Local
Neoplasm Staging
Prognosis
Salvage Therapy
Time Factors
| | Abstract | A (modified) radical mastectomy (RM) was compared with breast-conserving therapy (BCT) in stage I and stage II breast cancer patients. Treatment of the study arm comprised lumpectomy, axillary clearance and radiotherapy to the breast (50 Gy in 5 weeks external irradiation and a boost with iridium implant of 25 Gy). 902 patients were included. There were 734 TNM stage II patients. Patients with microscopically incomplete excision of the tumour were not excluded. After a median follow-up of 6 years, overall survival and local recurrence rates do not differ significantly between the two study arms. Actuarial survival at 8 years was 73% after RM and 71% after BCT; actuarial local recurrence at 8 years was 9% and 15%, respectively. In the mastectomy group tumour size did not affect local relapse, but after BCT the incidence of local recurrences was higher for tumours of 2-5 cm (16%) than for smaller tumours (7%) (at 8 years, P = 0.08). Results of salvage treatment for local recurrence so far were similar in both the BCT and the mastectomy group. | | Language | eng | | Pub Type(s) | Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
| | PubMed ID | 1524898 |
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