| Title | Vancomycin therapy and the progression of methicillin-resistant Staphylococcus aureus vertebral osteomyelitis. | | Author(s) | Gelfand MS, Cleveland KO | | Institution | Methodist University Hospital of Memphis, Memphis, TN, USA. msgelf@pol.net | | Source | South Med J 2004 Jun; 97(6):593-7. | | MeSH | Aged
Aged, 80 and over
Anti-Bacterial Agents
Bacteremia
Cross Infection
Disease Progression
Female
Humans
Male
Methicillin Resistance
Middle Aged
Osteomyelitis
Spinal Diseases
Staphylococcal Infections
Staphylococcus aureus
Vancomycin
| | Abstract | Vancomycin therapy is the standard treatment for methicillin-resistant Staphylococcus aureus (MRSA), the most common cause of vertebral osteomyelitis, an increasingly frequent complication of nosocomial bacteremia. We report five recent cases suggesting that, while giving the appearance of success by conventional clinical and laboratory criteria (eg, resolution of fever and leukocytosis), vancomycin monotherapy may in fact be insufficient to prevent or reverse the progression of hematogenous MSRA vertebral osteomyelitis. A review of the literature and possible therapeutic alternatives are also discussed. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 15255429 |
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