Acute superior mesenteric vein thrombosis associated with factor V 'Leiden' gene mutation. The Journal of the Association of Physicians of India. [J Assoc Physicians India] Journal article

OBJECTIVES: To study thrombophilia states in Indian patients with acute spontaneous superior mesenteric vein thrombosis (SMVT).
METHODS: Two men with this condition, a 56 year old and a 31 year old presenting with acute SMVT, demonstrated on CT scan, were subjected to a thrombophilia screen consisting of Protein C, S, antithrombin levels, lupus anticoagulant, anticardiolipin antibodies, fibrinogen levels, factor VIII levels, factor V 'Leiden' gene mutation, and paroxysmal nocturnal hematuria screen.
RESULTS: A thrombophilia screen showed factor V 'Leiden' gene mutation (heterozygous) in both cases. Additionally, the first patient had high fibrinogen levels and the second high factor VIII levels. Both patients are currently on long-term anticoagulation.
CONCLUSION: Factor V 'Leiden' gene mutation in association with other thrombophilic factors may predispose to spontaneous superior mesenteric vein thrombosis.

The Journal of the Association of Physicians of India. [J Assoc Physicians India]

Acute Disease
Adult
Factor V
Heterozygote
Humans
Male
Mesenteric Vascular Occlusion
Mesenteric Veins
Middle Aged
Mutation
Thrombophilia
Venous Thrombosis