| Title | Acute superior mesenteric vein thrombosis associated with factor V 'Leiden' gene mutation. | | Author(s) | Shah SR, Gupta AD, Sharma A, Joshi A, Desai D, Abraham P | | Institution | Section of GI Surgery, PD Hinduja National Hospital and Medical Research Centre, Mahim, Mumbai 400 016, India. | | Source | J Assoc Physicians India 2003 Jun.:611-3. | | MeSH | Acute Disease
Adult
Factor V
Heterozygote
Humans
Male
Mesenteric Vascular Occlusion
Mesenteric Veins
Middle Aged
Mutation
Thrombophilia
Venous Thrombosis
| | Abstract | OBJECTIVES: To study thrombophilia states in Indian patients with acute spontaneous superior mesenteric vein thrombosis (SMVT).
METHODS: Two men with this condition, a 56 year old and a 31 year old presenting with acute SMVT, demonstrated on CT scan, were subjected to a thrombophilia screen consisting of Protein C, S, antithrombin levels, lupus anticoagulant, anticardiolipin antibodies, fibrinogen levels, factor VIII levels, factor V 'Leiden' gene mutation, and paroxysmal nocturnal hematuria screen.
RESULTS: A thrombophilia screen showed factor V 'Leiden' gene mutation (heterozygous) in both cases. Additionally, the first patient had high fibrinogen levels and the second high factor VIII levels. Both patients are currently on long-term anticoagulation.
CONCLUSION: Factor V 'Leiden' gene mutation in association with other thrombophilic factors may predispose to spontaneous superior mesenteric vein thrombosis. | | Language | eng | | Pub Type(s) | Case Reports
Journal Article
| | PubMed ID | 15266932 |
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