Protein kinase C alpha expression in normal breast, ductal carcinoma in situ and invasive ductal carcinoma. European journal of cancer (Oxford, England : 1990) [Eur J Cancer] Journal article

Title	Protein kinase C alpha expression in normal breast, ductal carcinoma in situ and invasive ductal carcinoma.
Author(s)	Ainsworth PD, Winstanley JH, Pearson JM, Bishop HM, Garrod DR
Institution	Breast Unit, Royal Bolton Hospital, Minerva Road, Farnworth, Bolton, BL4 0JR, UK. drpaulainsworth@hotmail.com
Source	Eur J Cancer 2004 Oct; 40(15):2269-73.
MeSH	Breast Breast Neoplasms Carcinoma, Ductal, Breast Carcinoma, Intraductal, Noninfiltrating Female Humans Immunohistochemistry Neoplasm Proteins Protein Kinase C Protein Kinase C-alpha Research Support, Non-U.S. Gov't
Abstract	The purpose of this study was to determine if Protein Kinase C alpha (PKC alpha) is altered in expression or localisation in normal breast, ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC). We obtained 14 mixed cases of invasive ductal carcinoma (IDC) and DCIS, 36 pure DCIS cases and 25 cases of normal breast. The sections were stained immunohistochemically for PKC alpha expression. Staining was cytoplasmic. The results showed a progressive reduction in staining intensity from normal breast to invasive ductal carcinoma. The staining pattern was heterogeneous in the cytoplasm of DCIS and IDC, but homogeneous in the cytoplasm of normal breast ductal epithelium. Interestingly, mitotic cells and cells with aberrant nuclear morphology showed increased cytoplasmic staining in DCIS and IDC. PKC alpha activity is altered in dividing or abnormal cells, but overall expression is reduced in IDC. This raises the possibility of an alteration in the subcellular localisation of PKC alpha which may relate to changes in desmosomal adhesive state.
Language	eng
Pub Type(s)	Journal Article
PubMed ID	15454252

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