| Title | Evaluation of the anti-proliferative and anti-oxidative activities of leaf extract from in vivo and in vitro raised Ashwagandha. | | Author(s) | Kaur K, Rani G, Widodo N, Nagpal A, Taira K, Kaul SC, Wadhwa R | | Institution | Cell Proliferation Research Team, Gene Function Research Center, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki 305-8562, Japan. | | Source | Food Chem Toxicol 2004 Dec; 42(12):2015-20. | | MeSH | Antineoplastic Agents, Phytogenic
Antioxidants
Cell Aging
Cell Line, Tumor
Cell Survival
Cells, Cultured
Humans
Hydrogen Peroxide
Immunohistochemistry
Oxidants
Oxidative Stress
Plant Extracts
Plant Leaves
Withania
| | Abstract | Withania somnifera (Ashwagandha) is used in Indian traditional medicine, Ayurveda and is believed to have a variety of health promoting effects. Molecular mechanisms and pathways underlying these effects have not been studied. We tried to characterize various activities of leaf extract of Ashwagandha (Lash) raised in the field and in the laboratory. We found that the Lash from field-raised plants has a significant anti-proliferative activity in human tumorigenic cells. However, it did not impart any protection against the oxidative damage caused by high glucose and hydrogen peroxide to human tumor cells suggesting that it can be used as an anti-tumor, but not as an anti-oxidant, substance. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 15500938 |
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