| Title | Gene polymorphisms of the mu opioid receptor in methamphetamine abusers. | | Author(s) | Ide S, Kobayashi H, Tanaka K, Ujike H, Sekine Y, Ozaki N, Inada T, Harano M, Komiyama T, Yamada M, Iyo M, Ikeda K, Sora I | | Institution | Department of Molecular Psychiatry, Tokyo Institute of Psychiatry, Japan. | | Source | Ann N Y Acad Sci 2004 Oct.:316-24. | | MeSH | Adult
Amphetamine-Related Disorders
Chi-Square Distribution
Comparative Study
Female
Gene Frequency
Humans
Male
Methamphetamine
Monte Carlo Method
Polymorphism, Genetic
Receptors, Opioid, mu
Research Support, Non-U.S. Gov't
| | Abstract | In drug addiction, the opioid system is thought to mediate motivational effects through dopamine-independent mechanisms. We have investigated associations of the mu-opioid receptor gene (OPRM) variations with methamphetamine (MAP) dependence/psychosis. The allelic frequency of A118G (Asn40Asp) in exon 1 of ORPM was 45.3% in our control subjects, but only 7.5-25.8% in the Caucasian or African-American population of previous studies. We have identified several novel polymorphisms in intron 1 and the 5' untranslated region (5'UTR) of OPRM. Polymorphisms in the functionally relevant 5' regulatory region of OPRM were different in our Japanese population from Caucasian or African-American populations. No significant differences between controls and MAP abusers were found in either genotype or allele frequency at any single nucleotide polymorphism (SNP) or (AC)n dinucleotide repeat in intron 1. A subdivision of our MAP group revealed that A118G of OPRM shows a significant association with MAP psychosis having latency less than three years. Further analysis should be capable of identifying associations between the OPRM variations and MAP dependence/psychosis. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 15542732 |
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