| Title | Effect of nonselective and selective opioid receptors antagonists on antinociceptive action of acetaminophen [part III]. | | Author(s) | Bujalska M | | Institution | Department of Pharmacodynamics, Medical University of Warszawa, Krakowskie Przedmieście 26/28, PL 00-927 Warszawa, Poland. mbujalski@profilsp.com.pl | | Source | Pol J Pharmacol 2004 Sep-Oct; 56(5):539-45. | | MeSH | Acetaminophen
Analgesia
Analgesics
Animals
Comparative Study
Male
Narcotic Antagonists
Pain Measurement
Rats
Rats, Wistar
Receptors, Opioid
| | Abstract | The influence of naloxone (NAL), a competitive antagonist of mu, kappa, delta and sigma receptors; D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH(2) (CTOP), selective antagonist of mu-opioid receptors; nor-binaltorphimine (NOR-BNI), a potent and higly selective kappa opioid receptor antagonist; naltrindole (NTI), a delta-opioid receptor antagonist and naltriben (NTB), a highly selective delta(2)-opioid receptor antagonist on antinociceptive action of acetaminophen (ACETA) was studied in rats. NAL administered intraperitoneally (ip) or intracerebroventricularly (icv), and CTOP and NOR-BNI administered icv, markedly decreased the antinociceptive activity of the high dose of ACETA (400 mg/kg). Pretreatment with NTI (sc), as well as with naloxone (it), and NTB (it) slightly but significantly attenuated the ACETA antinociception. The possible involvement of the opioidergic systems in antinociceptive activity of ACETA is discussed. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 15591641 |
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