Timperley J, Mitchell AR, Thibault H, Mirza IH, Becher H
Safety of contrast dobutamine stress echocardiography: a single center experience. [Journal Article]
J Am Soc Echocardiogr 2005 Feb; 18(2):163-7.
BACKGROUND: Contrast is increasingly being used during dobutamine stress echocardiography. However, there are few data regarding the safety of this combination.
METHODS: We retrospectively analyzed 751 consecutive stress echocardiograms, 332 without contrast and 419 with contrast (299 with Sonouve, 120 with Optison). Reported side effects and physiologic data were then compared.
RESULTS: There were no fatalities. The incidence of side effects was similar in the 3 groups. The Optison group had a lower diastolic blood pressure compared with the noncontrast group ( P < .05) at rest, and the Sonovue group had a higher peak heart rate compared with the noncontrast group ( P < .001). Patients receiving Optison had more premature atrial contractions ( P < .05) but there was no difference in the incidence of ventricular tachycardia, supraventricular tachycardia, or vagally mediated episodes.
CONCLUSION: The use of contrast during dobutamine stress echocardiography was not associated with an increased risk of side effects.
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