Molecular and cellular mechanisms of lymphangiogenesis. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. [Eur J Surg Oncol] Journal article

Lymphangiogenesis is the growth and formation of new lymphatic vessels. It occurs in normally developing tissues and in pathological processes like inflammation, wound healing, lymphoedema and in cancer. New molecular markers that are specific to the lymphatic endothelium include: podoplanin, prox-1 and LYVE-1. The molecular mechanisms of lymphangiogenesis are not clear, but vascular endothelial growth factors (VEGF-C and VEGF-D) within tumours may simulate endothelial cells within tumour tissues to grow and generate new lymphatics. We report the current knowledge of molecular and cellular mechanisms of lymphangiogenesis.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. [Eur J Surg Oncol]

Biological Markers
Endothelial Cells
Endothelium, Lymphatic
Glycoproteins
Homeodomain Proteins
Humans
Lymphangiogenesis
Membrane Glycoproteins
Receptors, Growth Factor