Two new biologically active illudane sesquiterpenes from the mycelial cultures of Panaeolus retirugis. The Journal of antibiotics. [J Antibiot (Tokyo)] Journal article | | Title | Two new biologically active illudane sesquiterpenes from the mycelial cultures of Panaeolus retirugis. | | Author(s) | Ma W, Huang Y, Lin L, Zhu X, Chen Y, Xu H, Wei X | | Institution | South China Botanical Garden, Chinese Academy of Sciences, Leyiju, Guangzhou 510650, China. | | Source | J Antibiot (Tokyo) 2004 Nov; 57(11):721-5. | | MeSH | Anti-Bacterial Agents
Antibiotics, Antineoplastic
Basidiomycota
Cell Line, Tumor
Drug Screening Assays, Antitumor
Fermentation
Humans
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Optical Rotation
Research Support, Non-U.S. Gov't
Sesquiterpenes
Spectrometry, Mass, Electrospray Ionization
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Spectroscopy, Fourier Transform Infrared
| | Abstract | Two new illudane sesquiterpenes, paneolic acid and paneolilludinic acid, along with a known antibiotic diterpene, pleuromutilin, were isolated from the mycelial solid cultures of Panaeolus retirugis. Their structures were elucidated on the basis of spectroscopic analysis. Both compounds exhibited antibacterial activity against Staphylococcus aureus, and paneolic acid showed cytotoxicity to HL60 cell with an IC50 of 18.9 microg/ml. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 15712666 |
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