| Title | Assessment of percutaneous coronary intervention on regional and global left ventricular function in patients with chronic total occlusions. | | Author(s) | Ermis C, Boz A, Tholakanahalli V, Yalcinkaya S, Semiz E, Sancaktar O, Benditt DG, Deger N | | Institution | University of Akdeniz Medical School, Antalya, Turkey. | | Source | Can J Cardiol 2005 Mar; 21(3):275-80. | | MeSH | Angina Pectoris
Angina, Unstable
Angioplasty, Transluminal, Percutaneous Coronary
Chronic Disease
Coronary Stenosis
Echocardiography
Exercise Test
Female
Gated Blood-Pool Imaging
Humans
Male
Middle Aged
Patient Selection
Prospective Studies
Research Support, Non-U.S. Gov't
Risk Factors
Severity of Illness Index
Single-Blind Method
Stents
Stroke Volume
Thallium Radioisotopes
Time Factors
Treatment Outcome
Turkey
Ventricular Function, Left
| | Abstract | BACKGROUND: The improvement of regional and global ventricular function following percutaneous coronary intervention (PCI) with reperfusion of the artery supplying the infarct area in acute myocardial infarction is well-described. However, little is known of the potential effects of late recanalization of chronic coronary artery occlusion on left ventricular function.
OBJECTIVE: To determine whether PCI improves regional and global left ventricular function in patients with chronic coronary artery occlusions.
PATIENTS AND METHODS: Thirty-five patients having at least one coronary artery occluded for six weeks or longer were included in the present prospective study. Exercise thallium-201 myocardial perfusion scintigraphy, multiple-gated acquisition ventriculography and two-dimensional echocardiography were performed in 19 patients (16 men; mean age of 58+/-5 years) who underwent a successful PCI to assess both regional and global left ventricular function before and six weeks following the procedure.
RESULTS: The mean ejection fractions before and after reperfusion were 51+/-7% and 58+/-6% using Simpson's method (P<0.001) by echocardiography, and 45+/-1% and 53+/-1% (P=0.01) by multiple-gated acquisition ventriculography, respectively. The echocardiographic wall motion score was 24+/-9 before and 15+/-6 after PCI (P<0.001). The exercise perfusion score (21+/-1 and 14+/-1 [P=0.01]), rest perfusion score (15+/-1 and 12+/-1 [P=0.02]) and reinjection perfusion score (14+/-1 and 11.1+/-1 [P=0.07]) also improved after PCI. The presence of angina was strongly associated with an improvement in left ventricular function and wall motion score (P<0.01).
CONCLUSIONS: PCI significantly improved the regional and global left ventricular function in patients with chronic total coronary occlusion. This procedure may provide symptom benefits in selected patients. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 15776117 |
|
