| Title | Synthesis of novel N-substituted imidazolecarboxylic acid hydrazides as monoamine oxidase inhibitors. | | Author(s) | Hadizadeh F, Ghodsi R | | Institution | Pharmacy Faculty, Mashhad University of Medical Sciences, Mashhad, Iran. fhadizadeh@yahoo.com <fhadizadeh@yahoo.com> | | Source | Farmaco 2005 Mar; 60(3):237-40. | | MeSH | Humans
Hydrazines
Imidazoles
Isocarboxazid
Monoamine Oxidase
Monoamine Oxidase Inhibitors
Research Support, Non-U.S. Gov't
Structure-Activity Relationship
| | Abstract | Novel 2-alkylsulfanyl-1-benzyl-5-imidazolecarboxylic acid hydrazides (15a,b) were synthesized as analogues of isocarboxazide, which is a known nonselective irreversible monoamine oxidase inhibitor and tested for monoamine oxidase A and B inhibitory activity. Neither of the compounds showed any inhibition of MAO B activity up to a high concentration of 100 microM. An MAO A activity was only slowly inhibited at this high concentration after prolonged incubation with either compound. This suggests any observed inhibition is not very specific. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 15784243 |
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