Insulin, C-peptide, and leptin concentrations predict increased visceral adiposity at 5- and 10-year follow-ups in nondiabetic Japanese Americans. Diabetes [Diabetes] Journal article | | Title | Insulin, C-peptide, and leptin concentrations predict increased visceral adiposity at 5- and 10-year follow-ups in nondiabetic Japanese Americans. | | Author(s) | Tong J, Fujimoto WY, Kahn SE, Weigle DS, McNeely MJ, Leonetti DL, Shofer JB, Boyko EJ | | Institution | Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and Harborview Medical Center, University of Washington, Seattle, Washington 98108, USA. tongj@u.washington.edu <tongj@u.washington.edu> | | Source | Diabetes 2005 Apr; 54(4):985-90. | | MeSH | Abdomen
Adipose Tissue
Asian Americans
C-Peptide
Female
Glucose Tolerance Test
Humans
Insulin
Leptin
Male
Middle Aged
Obesity
Prospective Studies
Time Factors
| | Abstract | We prospectively examined the relationship between leptin and markers of insulin resistance and secretion and future visceral adipose tissue accumulation. In this study, 518 nondiabetic Japanese-American men and women underwent the following measurements at baseline and at 5- and 10-year follow-ups: plasma glucose and insulin measured after an overnight fast and during a 75-g oral glucose tolerance test, insulin secretion ratio (ISR) [(30-min insulin - fasting insulin)/30-min glucose], fasting C-peptide levels, plasma leptin (baseline only), and fat areas (intra-abdominal and subcutaneous) measured by computed tomography. Predictors of future intra-abdominal fat (IAF) were determined using multiple linear regression. Fasting insulin and C-peptide levels at baseline were significantly associated with IAF area at 5 years (coefficient = 0.041, P = 0.001 and coefficient = 1.283, P < 0.001, respectively) and 10 years (coefficient = 0.031, P = 0.020 and coefficient = 0.221, P = 0.035, respectively). ISR was not significantly associated with IAF at 5 or 10 years. Leptin level at baseline was positively associated with IAF at 5 years (coefficient = 0.055, P = 0.002) and 10 years (coefficient = 0.059, P = 0.003). In conclusion, higher levels of fasting insulin, C-peptide, and circulating leptin level predicted visceral fat accumulation independent from subcutaneous fat accumulation in nondiabetic Japanese-American men and women in both short-term (5 years) and long-term (10 years) follow-up. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.
| | PubMed ID | 15793236 |
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