| Title | Simultaneous analysis of the H1-antihistamine acrivastine and the decongestant pseudoephedrine hydrochloride by high-performance liquid chromatography. | | Author(s) | Gu X, Li H, Macnair KR, Simons FE, Simons KJ | | Institution | Faculty of Pharmacy, University of Manitoba, 50 Sifton Road, Winnipeg, Manitoba, Canada R3T 2N2. xgu@cc.umanitoba.ca | | Source | J Pharm Biomed Anal 2005 Apr 1; 37(4):663-7. | | MeSH | Calibration
Capsules
Chromatography, High Pressure Liquid
Ephedrine
Histamine H1 Antagonists
Nasal Decongestants
Pharmaceutical Solutions
Reference Standards
Reproducibility of Results
Solubility
Triprolidine
| | Abstract | High-performance liquid chromatography (HPLC) was used for the simultaneous quantification of the H(1)-antihistamine acrivastine and the decongestant pseudoephedrine hydrochloride. Both compounds were detected at the wavelength of 214 nm. The influence of the mobile phase and the detection wavelength was evaluated and optimized. This method was used to assay various samples from studies of the commercial preparation Semprex-D capsules. The method was found to be accurate, specific, selective, rapid, and versatile for use in routine quality control analyses. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 15797786 |
|
