Low-grade systemic inflammation, hypoadiponectinemia and a high concentration of leptin are present in very young obese children, and correlate with metabolic syndrome. Diabetes & metabolism. [Diabetes Metab] Journal article | | Title | Low-grade systemic inflammation, hypoadiponectinemia and a high concentration of leptin are present in very young obese children, and correlate with metabolic syndrome. | | Author(s) | Valle M, Martos R, Gascón F, Cañete R, Zafra MA, Morales R | | Institution | Basic Health Zone of Pozoblanco Córdoba, Spain. laboratorio.asnc.sspa@juntadeandalucia.es | | Source | Diabetes Metab 2005 Feb; 31(1):55-62. | | MeSH | Adiponectin
Blood Glucose
Blood Pressure
C-Reactive Protein
Child
Cross-Sectional Studies
Female
Fibrinogen
Homeostasis
Humans
Inflammation
Insulin
Intercellular Signaling Peptides and Proteins
Leptin
Lipids
Male
Metabolic Syndrome X
Obesity
Plasminogen Activator Inhibitor 1
Research Support, Non-U.S. Gov't
| | Abstract | OBJECTIVE: To determine the concentration levels of C-reactive protein (CRP), leptin and adiponectin in obese pre-pubertal children, and their possible relation with metabolic syndrome, fibrinogen and plasminogen activator inhibitor-1.
METHODS: A study was carried out in 51 obese children (aged 6 to 9 years) and the same number of non-obese children (control group), matched by age and sex. (Cross-sectional study of obese children). Body mass index (BMI), waist/hip ratio (WHR) and blood pressure were determined for each child. Serum CRP, leptin, adiponectin, glucose, insulin, lipid profile, plasminogen activator inhibitor-1 (PAI-1) and fibrinogen were all measured.
RESULTS: The levels of CRP serum (1.67+/-0.222 vs 0.92+/-0.16 mg/l) and leptin (15.56+/-1.27 vs 4.68+/-0.62 ng/ml) were significantly higher in obese children. The adiponectin level was significantly higher in non-obese children (11.58+/-0.63 vs 9.64+/-0.49 microg/dl). In the obese group, log. CRP showed a positive correlation with BMI, insulin, homeostasis model assessment (HOMA), triglycerides, alanine aminotransferase (ALT), uric acid, PAI-1, fibrinogen and interleukin 6 (IL-6), and correlated negatively with apolipoprotein A-I and high-density lipoprotein cholesterol (HDL-C). The leptin was positively correlated with BMI, insulin, HOMA, triglycerides and PAI-1 and negatively with Apo A-I and HDL-C. Adiponectin correlated negatively with BMI, insulin, HOMA, and triglycerides.
CONCLUSIONS: Low-grade systemic inflammation, elevated leptin concentration and low adiponectin level are described in very young obese children, correlating with a range of variables of metabolic syndrome. Inflammation and adipocytokines can play an important role in the etiopathogeny of metabolic syndrome. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 15803114 |
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