Effect of ketotifen fumarate, olopatadine, and levocabastine on ocular active anaphylaxis in the guinea pig and ocular immediate hypersensitivity in the albino rat. Ocular immunology and inflammation. [Ocul Immunol Inflamm] Journal article | | Title | Effect of ketotifen fumarate, olopatadine, and levocabastine on ocular active anaphylaxis in the guinea pig and ocular immediate hypersensitivity in the albino rat. | | Author(s) | Schoch C | | Institution | Novartis Pharma AG Basel Switzerland. christian.schoch@pharma.novartis.com | | Source | Ocul Immunol Inflamm 2005 Feb; 13(1):39-44. | | MeSH | Anaphylaxis
Animals
Capillary Permeability
Conjunctivitis, Allergic
Dibenzoxepins
Disease Models, Animal
Edema
Eyelids
Guinea Pigs
Histamine H1 Antagonists
Ketotifen
Male
Ophthalmic Solutions
Ovalbumin
Piperidines
Rats
Research Support, Non-U.S. Gov't
| | Abstract | PURPOSE: To study the effects of ketotifen fumarate, olopatadine, and levocabastine on ocular active anaphylaxis in guinea pigs and on ocular immediate hypersensitivity in albino rats.
METHODS: Clinical grading scores and Evans blue dye leakage to eyelids and to eyeballs were assessed in five treatment groups (n = 10): ketotifen fumarate 0.025%, olopatadine 0.1%, levocabastine 0.05%, negative control, and positive control.
RESULTS: At 20 minutes after challenge, edema scores for ketotifen-treated guinea pigs were statistically significantly lower than those for levocabastine or olopatadine. Active treatment significantly reduced vascular leakage in both models. Ketotifen significantly reduced vascular leakage in eyelids compared with the other drugs. In guinea pigs, vascular leakage in eyeballs was significantly reduced with ketotifen fumarate compared with olopatadine and levocabastine.
CONCLUSIONS: In the guinea pig model, ketotifen was more effective than olopatadine and levocabastine at reducing conjunctival edema and vascular permeability in eyelids and eyeballs. In the rat model, ketotifen was more effective at reducing vascular permeability in eyelids than olopatadine and levocabastine. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 15804768 |
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